Forty UPEC isolates were obtained, and urine morphotypes were observed in 65% of the urine samples from where E. The aim of this study was to determine the presence of bacterial morphotypes, virulence genes, virulence phenotypes, antibiotic resistant, and phylogenetic groups in clinical isolates of UPEC obtained from women in Sonora, Mexico. The development of morphotypes in UT represents an important feature of UPEC because it is associated with complications in diagnosis of UTI. UPEC possesses a wide diversity of virulence factors that allow it to carry out its pathogenesis mechanism in the urinary tract (UT). Abstract: Urinary tract infections (UTIs) belong to the most common pathologies in Mexico and are mainly caused by Uropathogenic Escherichia coli (UPEC). coli Diagnostic a Virulence-Phenotype-Phylogeny Study. Bacterial Morphotypes as Important Trait for Uropathogenic E. This review highlights the unique immune evasion and suppression strategies of this bacterial pathogen and offers directions for further study molecular understanding of these mechanisms will inform the development of adjunctive, anti-virulence therapeutics for UTI.Ĭitation: Ballesteros-Monrreal, M.G. Taken together, these attributes distinguish UPEC from commensal and nonpathogenic E. Recent work has also revealed novel mechanisms by which UPEC blunts neutrophil migration across infected uroepithelium.

To ensure the establishment of this protected niche, UPEC employ multiple strategies to attenuate and delay the initiation of host inflammatory components, including epithelial secretion of chemoattractants.

Early in acute cystitis, as demonstrated in murine models, UPEC gains access to an intracellular niche that protects a population of replicating bacteria from arriving phagocytes. In human UTI, this inflammatory response contributes to symptomatology and provides means for diagnosis by standard clinical testing. Introduction of UPEC into the mammalian urinary tract evokes a well-described inflammatory response, comprising pro-inflammatory cytokines and chemokines as well as cellular elements (neutrophils and macrophages). Uropathogenic Escherichia coli (UPEC) cause the majority of community-onset urinary tract infections (UTI) and represent a major etiologic agent of healthcare-associated UTI.

Subversion hosts